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Home      Products     Pharmaceutical Intermediates       881674-56-2 5-(2-Fluorophenyl)-1H-pyrrol
  • 881674-56-2 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde
  • 881674-56-2 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde
  • 881674-56-2 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde
  • 881674-56-2 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde
881674-56-2 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde881674-56-2 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde881674-56-2 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde881674-56-2 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde

881674-56-2 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde

5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde Basic information
Product Name: 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde
Synonyms: 1H-Pyrrole-3-carboxaldehyde, 5-(2-fluorophenyl)-;5-(2-fluorophenyl)-1H-pyrrole-3-carbaldehyde;5-(2-Fluorophenyl)-1H-pyrrole-3-carbal...;5-(2-Fluorophenyl)-1H-pyrrole-3-carboxaldehyde;1H-Pyrrole-3-carboxaldehyde, 5-(2-fluorophenyl)-1H-pyrrole-;TAK438 Impurity 54;1H-Pyrrole-3-carboxaldehyde, 5-(2-fluorophenyl)-1H-pyrrole-3-carbaldehyde;TAK-438( Vonoprazan fumarate) intermediate 3
CAS: 881674-56-2
MF: C11H8FNO
MW: 189.19
EINECS: 809-913-6
Product Categories: Vonoprazan;Pharmaceutical Intermediates;881674-56-2
Mol File: 881674-56-2.mol
5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde Structure
5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde Chemical Properties
Melting point  133 °C
Boiling point  370.6±32.0 °C(Predicted)
density  1.270±0.06 g/cm3(Predicted)
storage temp.  under inert gas (nitrogen or Argon) at 2-8°C
solubility  Chloroform (Slightly, Sonicated), DMSO (Slightly), Methanol (Slightly)
form  Solid
pka 14.77±0.50(Predicted)
color  Light Brown to Brown
Stability: Hygroscopic
InChI InChI=1S/C11H8FNO/c12-10-4-2-1-3-9(10)11-5-8(7-14)6-13-11/h1-7,13H
InChIKey MQULPEUCGKEHEG-UHFFFAOYSA-N
SMILES N1C(C2=CC=CC=C2F)=CC(C=O)=C1
Safety Information
HS Code  2933998090

MSDS Information
5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde Usage And Synthesis
Chemical Properties Light orange to Yellow to Green powder to crystal.
Uses 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde acts as a reagent in the synthetic preparation of novel pyrrole derivatives as potassium-competitive acid blocker (P-CAB).
Application 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde is a potassium ion-competitive acid blocker used in therapy Acid-related diseases, gastric ulcer, duodenal ulcer, reflux esophagitis, etc.
Preparation Synthesis of 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde: Using pyrrole as raw material, after being protected by N-alkylation of triisopropylsilyl chloride, it is then reacted with Vilsmeier reagent to obtain 1H-Pyrrole-3-carbaldehyde, which is then purified by N-bromosuccinimide (NBS) bromination and 2-fluorophenylboronic acid for Suzuki coupling reaction to obtain crude 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde, which was purified with toluene. The total yield was 35.5%.
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PREVIOUS：519032-08-7 4-PYRIMIDINECARBOXYLIC ACID, 1,6-DIHYDRO-5-HYDROXY-2-[1-METHYL-1-[[(PHENYLMETHOXY)CARBONYL]AMINO]ETHYL]-6-OXO-, METHYL ESTER NEXT：881677-11-8 1H-Pyrrole-3-carboxaldehyde, 5-(2-fluorophenyl)-1-(3-pyridinylsulfonyl)-

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