Welcome: Wuhan Yihe Technology Co., Ltd
en English
af Afrikaanssq Albanianam Amharicar Arabicfr Frenches Spanishru Russiande Germanhy Armenianit Italianja Japaneseko Koreanpt Portuguesehi Hindiaz Azerbaijaniro Romanianpl Polishth Thaiel Greekeu Basqueen Englishzh-CN Chinese (Simplified)zh-TW Chinese (Traditional)be Belarusianbn Bengalibs Bosnianbg Bulgarianca Catalanceb Cebuanony Chichewaco Corsicanhr Croatiancs Czechda Danishnl Dutcheo Esperantoet Estoniantl Filipinofi Finnishfy Frisiangl Galicianka Georgiangu Gujaratiht Haitian Creoleha Hausahaw Hawaiianiw Hebrewhmn Hmonghu Hungarianis Icelandicig Igboid Indonesianga Irishjw Javanesekn Kannadakk Kazakhkm Khmerku Kurdish (Kurmanji)ky Kyrgyzlo Laola Latinlv Latvianlt Lithuanianlb Luxembourgishmk Macedonianmg Malagasyms Malayml Malayalammt Maltesemi Maorimr Marathimn Mongolianmy Myanmar (Burmese)ne Nepalino Norwegianps Pashtofa Persianpa Punjabism Samoangd Scottish Gaelicsr Serbianst Sesothosn Shonasd Sindhisi Sinhalask Slovaksl Slovenianso Somalisu Sudanesesw Swahilisv Swedishtg Tajikta Tamilte Telugutr Turkishuk Ukrainianur Urduuz Uzbekvi Vietnamesecy Welshxh Xhosayi Yiddishyo Yorubazu Zulu
yihekeji@chembuying.com 86-18427358861
Home      Products     Pharmaceutical Intermediates       881674-56-2 5-(2-Fluorophenyl)-1H-pyrrol
  • 881674-56-2 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde
  • 881674-56-2 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde
  • 881674-56-2 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde
  • 881674-56-2 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde
881674-56-2 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde881674-56-2 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde881674-56-2 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde881674-56-2 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde

881674-56-2 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde

5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde Basic information
Product Name: 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde
Synonyms: 1H-Pyrrole-3-carboxaldehyde, 5-(2-fluorophenyl)-;5-(2-fluorophenyl)-1H-pyrrole-3-carbaldehyde;5-(2-Fluorophenyl)-1H-pyrrole-3-carbal...;5-(2-Fluorophenyl)-1H-pyrrole-3-carboxaldehyde;1H-Pyrrole-3-carboxaldehyde, 5-(2-fluorophenyl)-1H-pyrrole-;TAK438 Impurity 54;1H-Pyrrole-3-carboxaldehyde, 5-(2-fluorophenyl)-1H-pyrrole-3-carbaldehyde;TAK-438( Vonoprazan fumarate) intermediate 3
CAS: 881674-56-2
MF: C11H8FNO
MW: 189.19
EINECS: 809-913-6
Product Categories: Vonoprazan;Pharmaceutical Intermediates;881674-56-2
Mol File: 881674-56-2.mol
5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde Structure
5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde Chemical Properties
Melting point  133 °C
Boiling point  370.6±32.0 °C(Predicted)
density  1.270±0.06 g/cm3(Predicted)
storage temp.  under inert gas (nitrogen or Argon) at 2-8°C
solubility  Chloroform (Slightly, Sonicated), DMSO (Slightly), Methanol (Slightly)
form  Solid
pka 14.77±0.50(Predicted)
color  Light Brown to Brown
Stability: Hygroscopic
InChI InChI=1S/C11H8FNO/c12-10-4-2-1-3-9(10)11-5-8(7-14)6-13-11/h1-7,13H
InChIKey MQULPEUCGKEHEG-UHFFFAOYSA-N
SMILES N1C(C2=CC=CC=C2F)=CC(C=O)=C1
Safety Information
HS Code  2933998090

MSDS Information
5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde Usage And Synthesis
Chemical Properties Light orange to Yellow to Green powder to crystal.
Uses 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde acts as a reagent in the synthetic preparation of novel pyrrole derivatives as potassium-competitive acid blocker (P-CAB).
Application 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde is a potassium ion-competitive acid blocker used in therapy Acid-related diseases, gastric ulcer, duodenal ulcer, reflux esophagitis, etc.
Preparation Synthesis of 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde: Using pyrrole as raw material, after being protected by N-alkylation of triisopropylsilyl chloride, it is then reacted with Vilsmeier reagent to obtain 1H-Pyrrole-3-carbaldehyde, which is then purified by N-bromosuccinimide (NBS) bromination and 2-fluorophenylboronic acid for Suzuki coupling reaction to obtain crude 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde, which was purified with toluene. The total yield was 35.5%.
Tags:
PREVIOUS：519032-08-7 4-PYRIMIDINECARBOXYLIC ACID, 1,6-DIHYDRO-5-HYDROXY-2-[1-METHYL-1-[[(PHENYLMETHOXY)CARBONYL]AMINO]ETHYL]-6-OXO-, METHYL ESTER NEXT：881677-11-8 1H-Pyrrole-3-carboxaldehyde, 5-(2-fluorophenyl)-1-(3-pyridinylsulfonyl)-

RELATED PRODUCTS

694-48-4 1,3-Dimethylpyrazole

694-48-4 1,3-Dimethylpyrazole

122-37-2 4-Hydroxydiphenylamine

122-37-2 4-Hydroxydiphenylamine

917389-21-0 4-Quinazolineacetic acid, 8-fluoro-1,2,3,4-tetrahydro-3-[2-Methoxy-5-(trifluoroMethyl)phenyl]-2-oxo-, Methyl ester

917389-21-0 4-Quinazolineacetic acid, 8-fluoro-1,2,3,4-tetrahydro-3-[2-Methoxy-5-(trifluoroMethyl)phenyl]-2-oxo-, Methyl ester

17814-85-6 (4-Carboxybutyl)triphenylphosphonium bromide

17814-85-6 (4-Carboxybutyl)triphenylphosphonium bromide

CATEGORIES

LATEST NEWS

CONTACT US

Name: Eric Yuan

Mobile：86-18427358861

Tel：86-18427358861

Whatsapp：+86 18427358861

Email：yihekeji@chembuying.com

Add：